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Homocysteine thiolactone as precursor of methionine amide : application to the modification of peptides of the tachykinin family

✍ Scribed by G. Chassaing; S. Lavielle; S. Julien; A. Marquet

Book ID: 104222355
Publisher: Elsevier Science
Year: 1985
Tongue: French
Weight: 159 KB
Volume: 26
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)89163-7

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✦ Synopsis

Two pathways for the substitution of a tert-butyl group from (S-tert-butyll-homocysteine by an alkyl residue are described. Pathway B via homocysteine thiolactone, can be used to modify any peptide containing a C-terminal methionine amide. The neuropeptide Substance P, (SP), is a member of the tachykinin family, a group of peptides which share, among other common features,a C-terminal methionine amide (11. Recently, two other tachykinins, NKA and NKB, (Z-51 have been found in the central nervous system and

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