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Homocysteine induces DNA damage and alterations in proliferative capacity of T-lymphocytes: a model for immunosenescence?

✍ Scribed by Isa Picerno; Cristina Chirico; Salvatore Condello; Giuseppa Visalli; Nadia Ferlazzo; Gaetano Gorgone; Daniela Caccamo; Riccardo Ientile


Publisher
Springer
Year
2006
Tongue
English
Weight
236 KB
Volume
8
Category
Article
ISSN
1389-5729

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✍ Randall Reynolds; Sam Witherspoon; Tony Fox 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 239 KB

## Abstract The present work describes the use of the infant (4‐wk‐old) mouse as an animal model for the study of DNA damage–induced G~1~ checkpoint response, changes in p53 protein levels, and multiple gene expression changes after DNA damage has been induced in the liver. Hepatocytes in the infan