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Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials

โœ Scribed by Robert Clarke; Jim Halsey; Derrick Bennett; Sarah Lewington


Book ID
106374686
Publisher
Springer
Year
2010
Tongue
English
Weight
163 KB
Volume
34
Category
Article
ISSN
0141-8955

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Elevated plasma total homocysteine (tHcy) is a risk factor for atherosclerosis. Hcy is 70-80% bound to albumin as a disulfide. Recent trials have evaluated ability of thiol-containing drugs to exchange with protein bound Hcy and consequently increase its renal clearance. The objective of this study