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Homeostatic adaptations in brain energy metabolism in mouse models of Huntington disease

✍ Scribed by Tkac, Ivan; Henry, Pierre-Gilles; Zacharoff, Lori; Wedel, Michael; Gong, Wuming; Deelchand, Dinesh K; Li, Tongbin; Dubinsky, Janet M

Book ID
115483194
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
724 KB
Volume
32
Category
Article
ISSN
0271-678X

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## Abstract Huntington disease (HD) is an autosomal dominant disorder in which degeneration of medium‐sized spiny striatal neurons occurs. The HD gene and the protein it encodes, huntingtin, have been identified but their functions remain unknown. Transgenic mouse models for HD have been developed