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Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

โœ Scribed by Parijs, L. V.


Book ID
119975397
Publisher
American Association for the Advancement of Science
Year
1998
Tongue
English
Weight
431 KB
Volume
280
Category
Article
ISSN
0036-8075

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โœฆ Synopsis


The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.


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