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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

✍ Scribed by D'Orazi, Gabriella; Cecchinelli, Barbara; Bruno, Tiziana; Manni, Isabella; Higashimoto, Yuichiro; Saito, Shin'ichi; Gostissa, Monica; Coen, Sabrina; Marchetti, Alessandra; Del Sal, Giannino


Book ID
109912561
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
442 KB
Volume
4
Category
Article
ISSN
1465-7392

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## Abstract Human MCF‐7 breast cancer cells are relatively resistant to conventional chemotherapy due to the lack of caspase‐3 activity. We reported recently that roscovitine (ROSC), a potent cyclin‐dependent kinase 2 inhibitor, arrests human MCF‐7 breast cancer cells in the G~2~ phase of the cell