✦ LIBER ✦

Homeobox genes and development of the vertebrate CNS

✍ Scribed by David G. Wilkinson

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 588 KB
Volume: 10
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950100211

No coin nor oath required. For personal study only.

✦ Synopsis

The discovery of homeobox genes in vertebrates may allow analysis of a basic problem in developmental neurobiology : how regional digerences in CNS organization are specified during development. This view is based on the roles defined for homologous genes in Drosophila development, and is supported by studies of the patterns of homeobox gene expression in vertebrate embryos. Homeobox genes comprise a multigene family, members of which are expressed in dixerent spatially restricted domains along the anteriorposterior axis of the CNS. These observations are consistent with homeobox genes having roles in the positional speciJication of CNS organization, and experimental tests of this should be forthcoming shortly.

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