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Homeobox gene expression in human oocytes and preembryos

✍ Scribed by Yury Verlinsky; Gennedy Morozov; Viktor Gindilis; Charles M. Strom; Michael Freidin; Svetlana Rechitsky; Oleg Verlinsky; Victor Ivakhnenko; Valery Zdanovsky; Anver Kuliev

Book ID
102528979
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
481 KB
Volume
41
Category
Article
ISSN
1040-452X

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✦ Synopsis

Abstract

Homeobox gene expression in human preimplantation development has not been established. We used reverse transcriptase‐polymerase chain reaction (RT‐PCR) with intron spanning primer sets to investigate the presence of mRNA of homeobox genes in human oocytes and preembryos. RT‐PCR products obtained from normal and unfertilized oocytes, from cleaving normal and triploid embryos, and from morulae and blastocysts were cloned, sequenced, and analyzed for the presence of homeobox sequences. The presence of mRNA of homeoboxes HoxA4 and HoxA7 was demonstrated; HoxA4 was present in normal and unfertilized oocytes and also in a 4‐cell embryo. HoxA7 was present in normal oocytes and cleaving triploid embryos. Β© 1995 Wiley‐Liss, Inc.

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