Hollow-fibre enzyme reactor integrated with solvent extraction for synthesis of aspartame precursor

Performance of Perstractive Enzyme React

Performance of Perstractive Enzyme Reactor for Synthesis of Aspartame Precursor

✍ Yasuyuki Isono; Kenji Fukushima; Gen-ichiro Araya; Hiroshi Nabetani; Mitsutoshi 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 437 KB

A perstractive enzyme reactor was used for the synthesis of N-(benzyloxycarbonyl)-L-aspartyl-L-phenylalanine methyl ester (ZAPM), the precursor of the artiÐcial sweetener, aspartame. The synthesis of ZAPM in the reactor proceeded by an enzymatic reaction between N-(benzyloxycarbonyl)-Laspartic acid