Hodgkin'S disease associated with human immunodeficiency virus infection. A clinical study of 46 cases

✍ Scribed by Rafael Rubio

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 689 KB
• Volume: 73
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19940501)73:9<2400::aid-cncr2820730925>3.0.co;2-c

✦ Synopsis

Background. Hodgkin's disease is not an acquired immunodeficiency syndrome (AIDS)-defining illness. However, Hodgkin's disease associated with human immunodeficiency virus (HIV) infection has a different natural history and therapeutic outcome than in the general population of Hodgkin's disease patients.

Methods. The authors studied the epidemiologic and clinicopathologic features and therapeutic outcomes of 46 patients with Hodgkin's disease associated with HIV infection collected from a cooperative study of nine hospitals in Madrid, Spain.

Results. Forty-three (93.5%) of the subjects were men and three (6.5%) were women, with a mean age of 26.9 years. Thirty-nine (84.8%) were intravenous drug users and four (8.7%) were homosexuals. In 43 patients (93.5%), Hodgkin's disease was the first manifestation of HIV infection. In 16 patients (34.8%), AIDS developed after the diagnosis of Hodgkin's disease. Histologic subtypes were mixed cellularity (41.3%), lymphoid depletion (21.7%), nodular sclerosis (21.7%), and lymphocytic predominance (4.3%). At diagnosis, 89.1% had advanced stages (III,IV), 82.6% had B symptoms, and 41.3% had bone mar-From the Unidad lnfeccion HIV, Hospital "12 de Octubre," Madrid, Spain.

The following persons and institutions were participants in this study by the Cooperative Study Group of Malignancies Associated to HIV Infection of Madrid (Spain). Hospital "12 de Octubre":