Hodgkin disease in patients 60 years of age or older. Histologic and clinical features of advanced-stage disease

✍ Scribed by Rabia Mir; James Anderson; James Strauchen; Nis I. Nissen; M. Robert Cooper; Sameer Rafla; George P. Canellos; Clara D. Bloomfield; Arlan J. Gottlieb; Bruce Peterson; Maurice Barcos; Cancer; Leukemia Group B

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 904 KB
• Volume: 71
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19930301)71:5<1857::aid-cncr2820710524>3.0.co;2-b

✦ Synopsis

Background. This article reviews the salient pathologic and clinical features of 171 patients with Stage III-IV disease who were 60 years of age or older who were treated on four Hodgkin disease (HD) protocols from 1969 to 1988.

Methods. Pretherapy sections were reviewed centrally for correlation of the histologic classification with anatomic sites of involvement and survival.

Results. The diagnosis of HD was confirmed in 114 (66.7%) patients. Non-Hodgkin lymphomas (NHL) and a miscellaneous non-HD group accounted for 52 (30.4%) and 5 (2.90/,) of the cases. The overall median survival times of patients with Stage 111-IV HD and NHL who were 60 years of age or older in the four protocols were not significantly different (1.5 versus 1.3 years, respectively; P = 0.28). There also was no significant correlation between the survival of these patients with HD and either the Rye classification, 19 specific histologic parameters, or the British National Lymphoma Investigation