Hodgkin disease clinical stages I, II, and III (A, B): Results of radiotherapy with or without chemotherapy

✍ Scribed by M. Brites Patricio; J. A. Ricardo; M. Vilhena; F. Branco; M. A. de Ponte; R. Cabral; M. Neves; J. V. de Sousa

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 390 KB
• Volume: 24
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930240321

✦ Synopsis

Between 1961 and 1976, 387

patients with Hodgkin disease were examined, evaluated, and treated at the lnstituto Portugues de Oncologia de Francisco Gentil. After reviewing histological and clinical staging presentation, the authors retrospectively analyzed the results obtained with 303 patients classified in clinical stages I, 11, and I11 (A, B) who were treated with or without chemotherapy in two time periods (before and after 1970) according to individual therapeutic modalities. The improvement of the 5- year survival rates in the lasl period was associated with the introduction of extended-field irradiation and multidrug chemotherapy (MOPP). However, the incidence of serious complications was higher in the group of patients subjected to combined field irradiation and MOPP. The authors suggest a stricter protocol based on the current recommendations for the treatment of Hodgkin disease in order to achieve better results with minimum possible hazards.