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hnRNP K: An HDM2 Target and Transcriptional Coactivator of p53 in Response to DNA Damage

✍ Scribed by Abdeladim Moumen; Philip Masterson; Mark J. O'Connor; Stephen P. Jackson


Book ID
116352810
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
772 KB
Volume
123
Category
Article
ISSN
0092-8674

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula