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HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLα and hMLH1–hEXO1 complexes

✍ Scribed by Jäger, Anne Charlotte; Rasmussen, Merete; Bisgaard, Hanne Cathrine; Singh, Keshav K; Nielsen, Finn Cilius; Rasmussen, Lene Juel


Book ID
110064743
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
402 KB
Volume
20
Category
Article
ISSN
0950-9232

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Our previous studies of lung cancer in chromate-exposed workers (chromate lung cancer) have revealed that the frequency of replication error (RER) in chromate lung cancer is very high. We examined whether the RER phenotype of chromate lung cancer is due to an abnormality of DNA mismatch repair prote