Human renal cell carcinoma (RCC) is a common malignant disease of the kidney characterized by dedifferentiation of renal epithelial cells. Our previous experiments showed that most RCCs have a loss of function of the tissue-specific transcription factor hepatocyte nuclear factor (HNF) 1α. Detailed a
✦ LIBER ✦
HNF4α reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma
✍ Scribed by Lucas, Belén; Grigo, Karen; Erdmann, Silke; Lausen, Jörn; Klein-Hitpass, Ludger; Ryffel, Gerhart U
- Book ID
- 110069839
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 450 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The __enhancer of zeste homolog 2__ (__EZH2__) gene has been recently linked to human malignancies where it may serve as a new target for cancer therapy. Here, we analyzed __EZH2__ expression in primary renal cell carcinoma (RCC) specimens and in nontumorous tissue samples from adult ki
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