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HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages

✍ Scribed by Piotr Nowak; Babilonia Barqasho; Carl Johan Treutiger; Helena Erlandsson Harris; Kevin J. Tracey; Jan Andersson; Anders Sönnerborg

Book ID
116397720
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
154 KB
Volume
34
Category
Article
ISSN
1043-4666

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## Abstract ## Background HIV‐1 integrase (IN) is an interesting target for the gene therapy of AIDS. Although the __in vivo__ functions are not well characterized, it is thought that IN has pleiotropic effects and plays a central role in the interplay between the virus and the host cell. Expressi