HLA—Bw35 and Prognosis in Adult Still's Disease

✍ Scribed by Robert Terkeltaub; John M. Esdaile; Francine Décary; Manfred Harth; John Lister; Normand Lapointe

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 378 KB
• Volume: 24
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780241203

✦ Synopsis

Abstract

Twenty‐five patients with adult Still's disease were studied to determine clinical course and possible HLA associations. Two types of disease evolution were distinguishable clinically: a self‐limited remitting disease with or without recurrent cyclic exacerbations was found in 11 patients, and a persistent disease with continuous activity for more than 1 year, generally accompanied by progressive joint disease, was determined in 8. Disease course could not be classified in 6 patients. The antigen frequencies of HLA—Bw35 (40%, P < 0.05) and Cw4 (44%, P < 0.05) were increased in adult Still's disease as compared to controls (18% and 20%, respectively). Because HLA—Bw35 was associated with the self‐limited remitting type disease (P < 0.02), this antigen may be a favorable prognostic marker in adult Still's disease.