HLA–B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats

HLA–B27 up-regulation causes accumulatio

HLA–B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease

✍ Matthew J. Turner; Monica L. DeLay; Shuzhen Bai; Erin Klenk; Robert A. Colbert 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 1 views

Objective. HLA-B27 is implicated in the pathogenesis of spondylarthritis (SpA), yet the molecular mechanisms are incompletely defined. HLA-B27 misfolding has been associated with endoplasmic reticulum stress and activation of the unfolded protein response (UPR) in macrophages from HLA-B27/human ␤ 2