HLA-type of cerebral vasospasm patients after aneurysmal subarachnoid hemorrhage
β Scribed by Jun Sakaguchi; Mikihiko Takeshita; Mizuo Kagawa; Masahiro Izawa; Kintomo Takakura
- Publisher
- Springer-Verlag
- Year
- 1994
- Tongue
- English
- Weight
- 366 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0344-5607
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β¦ Synopsis
We studied human lymphocyte antigen (HLA) types in a group of 45 patients who had aneurysmal subarachnoid hemorrhage (SAH). A significantly increased frequency of HLA antigen A31 and a significantly decreased frequency of HLA antigen B40 were found. In patients with delayed ischemic neurological deficit (DIND) following aneurysmal SAH and HLA typing, HLA-Bw60 antigen showed significant increases; in patients who did not develop HLA-Aw33 and -Cw4 antigens showed significant. Among the patients with Fisher's Group 3 on CT, in particular, these antigens significantly increased when compared with controls from the same geographic area. These results suggest that HLA-Bw60 antigen plays a role as predisposing factor of DIND resulting from vasospasm following aneurysmal SAH, and that HLA-Aw33 and -Cw4 exert protective influence against DIND.
π SIMILAR VOLUMES
## Abstract Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of