𝔖 Bobbio Scriptorium
✦   LIBER   ✦

HLA-type of cerebral vasospasm patients after aneurysmal subarachnoid hemorrhage

✍ Scribed by Jun Sakaguchi; Mikihiko Takeshita; Mizuo Kagawa; Masahiro Izawa; Kintomo Takakura


Publisher
Springer-Verlag
Year
1994
Tongue
English
Weight
366 KB
Volume
17
Category
Article
ISSN
0344-5607

No coin nor oath required. For personal study only.

✦ Synopsis


We studied human lymphocyte antigen (HLA) types in a group of 45 patients who had aneurysmal subarachnoid hemorrhage (SAH). A significantly increased frequency of HLA antigen A31 and a significantly decreased frequency of HLA antigen B40 were found. In patients with delayed ischemic neurological deficit (DIND) following aneurysmal SAH and HLA typing, HLA-Bw60 antigen showed significant increases; in patients who did not develop HLA-Aw33 and -Cw4 antigens showed significant. Among the patients with Fisher's Group 3 on CT, in particular, these antigens significantly increased when compared with controls from the same geographic area. These results suggest that HLA-Bw60 antigen plays a role as predisposing factor of DIND resulting from vasospasm following aneurysmal SAH, and that HLA-Aw33 and -Cw4 exert protective influence against DIND.


πŸ“œ SIMILAR VOLUMES


Pathogenesis of cerebral vasospasm follo
✍ Angelos G. Kolias; Jon Sen; Antonio Belli πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 130 KB

## Abstract Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of