HLA-G transgenic mice
β Scribed by Andrew Mellor; Min Zhou; Simon J Conway; David Munn
- Book ID
- 114133164
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 132 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0165-0378
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π SIMILAR VOLUMES
In a previous report we described how cross-immunizations of pairs of transgenic mice expressing different HLA class I antigens led to the production of antibodies directed exclusively at polymorphic epitopes. This was ascribed to self-tolerance of HLA that prevents immune responses to monomorphic e
## Abstract HLAβtransgenic mice have been developed to facilitate studies of HLAβrestricted cytotoxic responses, __e.g.,__ for the identification of immunodominant HLAβrestricted CTL epitopes and the optimization of peptide or DNA vaccine constructs for human use. We have developed HLAβA2402/K^b^βt