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HLA frequencies in primary immunodeficiency diseases (PIDD)

✍ Scribed by K. -G. Evers; J. Krüger; R. Hägele; W. Haase; B. Leven

Publisher
Springer
Year
1977
Tongue
English
Weight
281 KB
Volume
124
Category
Article
ISSN
0340-6997

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✦ Synopsis

Thirteen patients with primary immunodeficiency disorders and their twenty-five healthy first-degree relatives were tissue typed and their HLA make-up was compared with that of a normal control population. HLA-A2 occured in 92.3% of patients as opposed to 60.8% in the control group (P less than 0.02), HLA-A9 in 7.6% vs. 25% (P less than 0.02) and HLA-B8 in 0% vs. 21% (P less than 0.04). One of the patients with severe combined immunodeficiency showed one "extraneous" HLA specifity.

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Over 120 inherited primary immunodeficiency diseases (PIDs) are known to exist. The genes responsible for many of these diseases have also been identified. Recent advances in diagnostic procedures have enabled these to be identified earlier and appropriately treated. While a number of approaches are