HLA DR-DQ disease associations with cervical carcinoma show human papillomavirus-type specificity
β Scribed by Apple, R.J.; Wheeler, C.M.; Klitz, W.; Manos, M.M.; Becker, T.M.; Erlich, H.A.
- Book ID
- 122727360
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 160 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0198-8859
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## Abstract We have previously shown that high human papillomavirus (HPV) 16 load in Papanicolaou smears negative for dysplasia is strongly associated with risk for carcinoma __in situ__ (CIS) of the cervix. Here we study the amount of HPV DNA for some of the most frequent highβrisk HPV types as de
Human papillomavirus (HPV) 16 and HPV18 E2 amino acid variants and host HLA DR/DQ haplotypes have been identified by direct nucleic acid sequencing from cervical scrapes. HPV16 E2 variants co-segregate with a nucleotide variant at nt350 (in E6), which previously has been associated with persistent i