✦ LIBER ✦
HLA-DQ polymorphism analyzed by sequential restriction endonuclease DNA digestion
✍ Scribed by Massimo Trucco; Sharon Rosenshine; Isabella Cascino; René J. Duquesnoy
- Book ID
- 104741341
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 696 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
A direct, physical correspondence between certain Pst I-generated genomic DNA fragments and Taq I-generated fragments, revealed with HLA-DQ alpha or -DQ beta gene probes, has been demonstrated. As an immediate consequence, the nature of the DQ and DX hybridized genes contained in the fragments was established. Taq I-generated DQ allelic forms which associate with serologically defined DR1, DR2, and DRw6 specificities were also proven to be sensu stricto "splits" of the Pst I-generated allelic form associated with all three DR specificities.