HLA class-II antigen-mediated induction of a proliferative response to anti-IgM in human B lymphocytes
✍ Scribed by N. Mooney; D. van Alewyk; C. Brick-Ghannan; D. Charron
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 347 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Signal transduction via HLA class-ll antigens has been studied using human resting B lymphocytes and monoclonal anti-HLA class-ll antibodies. An increased intracellular calcium flux, phosphatidylinositol biphosphate hydrolysis and activation of protein kinase C have all been observed following signal transduction via HLA-class-ll molecules. The interaction of HLA-class-Il-mediated signalling with slg-mediated signalling has been studied using a non-mitogenic anti-slg. This combination provides a model for T-cell-dependent antigenic stimulation. The results demonstrate that stimulation via HLA class-ll antigens permits a proliferative response to an otherwise non-mitogenic anti-slg and that this effect is not restricted to one HLA class-ll isotype. These data suggest that HLA-class-ll-mediated signalling is important in responses to T-cell-dependent antigens.