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HLA associations in insulin-dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population

✍ Scribed by A. Svejgaard; B. K. Jakobsen; P. Platz; L. P. Ryder; J. Nerup; M. Christy; K. Borch-Johnsen; H.-H. Parving; T. Deckert; L. Mølsted-Pedersen; C. Kühl; K. Buschard; A. Green


Book ID
115093787
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
485 KB
Volume
28
Category
Article
ISSN
0001-2815

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Inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus is partly determined by HLA genes. It has been suggested that protection from disease may be conferred by HLA-DQB1 genes which encode molecules with aspartate at position 57. We investigated the contributions of HLA-DRB1, DQA1