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HLA antigens in relationship to duodenal ulceration, gastric acid secretion and the clinical result following vagotomy

โœ Scribed by M. J. Gough; S. M. Rajah; G. R. Giles


Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
367 KB
Volume
69
Category
Article
ISSN
0007-1323

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โœฆ Synopsis


Abstract

The distribution of 20 HLA antigens was measured in 100 patients with a duodenal ulcer. An increase (P < 0ยท05) in the incidence of the HLA-BW35 antigen was identified which conferred an increased risk factor of developing a duodenal ulcer of 2ยท7. The preoperative acid output in patients who had the BW35 antigen was significantly lower than that found in all other patients prior to surgery. The clinical outcome from definitive surgical treatment did not appear to be influenced by the HLA status of the patients.


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