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HLA-antigens and the prognosis of multiple sclerosis

✍ Scribed by Sigrid Poser; G. Ritter; H. J. Bauer; H. Grosse-Wilde; E. K. Kuwert; N. E. Raun

Publisher
Springer
Year
1981
Tongue
English
Weight
143 KB
Volume
225
Category
Article
ISSN
0340-5354

No coin nor oath required. For personal study only.

✦ Synopsis

The histocompatibility pattern of 160 patients with multiple sclerosis (MS) living in the epidemiological area of Southern Lower Saxony was determined and compared to a control population. The only significant difference was the more frequent occurrence of DW2 in the patient group (44% vs. 21%). Taking a progression index (grade of disability divided by the duration of the disease) as a measure for prognosis no difference could be found between the DW2 positive and the DW2 negative patients. The reason why we could not confirm the worse prognosis for DW2 positive patients found by Jersild et al. (1973) and Raun et al. (1980) remains to be investigated.

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