HLA-Antigenfrequenzen bei Patienten mit progressiver Sklerodermie und Morphaea

✍ Scribed by J. Freudenberg; H. Holzmann; S. Schneider; G. W. Korting

• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 492 KB
• Volume: 263
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00446441

✦ Synopsis

Forty three patients with progressive systemic sclerosis and 24 patients with morphea are typed for 30 antigens of the HLA-A and B series. There is an increase of the frequency of HLA-B8 in patients with progressive systemic sclerosis (37% vs. 20% in controls: P less than 0.001, Pcorr. = n.s.). The increase of the HLA-B8 frequency seems to be most pronounced in patients with a diffuse form of progressive systemic sclerosis. 4 out of 5 patients are HLA-B8 positive (P = 0.00672). In patients with acrosclerosis is HLA-B8 only slightly increased (32%), but the increase is greater in male patients (44%) and in patients with an early onset of the disease (36%). With the exception of HLA-A1 there is no deviation of the frequencies of any other HLA antigen tested, especially not of HLA-Aw24. The number of patients with morphea is to small for statistical evaluation.