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HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance

✍ Scribed by Campoli, M; Ferrone, S

Book ID
109970599
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
479 KB
Volume
27
Category
Article
ISSN
0950-9232

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The tissue distribution of HLA-G molecules is broader than originally reported in trophoblastic cells. On the basis of numerous studies, HLA-G is also expressed in malignant tumors and involved in tumor immune escape. The mechanisms of HLA-G gene regulation differ from those of classical HLA class I