HLA and schizophrenia: Refutation of reported associations with A9 (A23/A24), DR4, and DQ?1*0602

✍ Scribed by Gibson, Stephanie; Hawi, Ziarih; Straub, Richard E.; Walsh, Dermot; Kendler, Kenneth S.; Gill, Michael

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 18 KB
• Volume: 88
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19990820)88:4<416::aid-ajmg21>3.0.co;2-s

✦ Synopsis

The aim of this study was to test previous hypotheses of association between schizophrenia and human leukocyte antigen (HLA) specificities A9 (A23/24), DR4, and allele DQ␤1*0602. Using sequence-specific oligonucleotide probes, 256 familial schizophrenic patients and 261 unrelated controls were genotyped at polymorphisms for HLA-A, DR␤1, and DQ␤1 loci. No significant (p < 0.05) differences in the allele frequencies between schizophrenics and controls were found, either when examining the sample as a whole or when subdivided by clinical subtype or gender. The present data do not support association between these HLA specificities and schizophrenia, and our review of previous studies suggests that reported associations may well be false positive results. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:416-421, 1999.