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HLA and other host factors in transfusion-acquired HIV-1 infection

✍ Scribed by Andrew F Geczy; Harmjan Kuipers; Marcel Coolen; Lesley J Ashton; Craig Kennedy; Gwen Ng; Rebecca Dodd; Rhonda Wallace; Trang Le; Camille H Raynes-Greenow; Wayne B Dyer; Jennifer C Learmont; John S Sullivan

Book ID
117415972
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
171 KB
Volume
61
Category
Article
ISSN
0198-8859

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Recent studies suggest that the pathogenesis of HIV infection and AIDS involves two distinct phases. During acute infection, massive depletion of CD4 + CCR5 + memory T cells within the mucosal-associated lymphoid tissue leads to major and potentially irreversible damage to CD4 + T-cell-mediated immu