HLA and Disease Associations

✍ Scribed by Jawahar L. Tiwari Ph.D., Paul I. Terasaki Ph.D. (auth.)

• Publisher: Springer-Verlag New York
• Year: 1985
• Tongue: English
• Leaves: 491
• Edition: 1
• Category: Library

✦ Synopsis

The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter­ national histocompatibility workshops held during this period. Although iden­ tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un­ expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

✦ Table of Contents

Front Matter....Pages i-xxiii
HLA Nomenclature....Pages 1-3
The HLA Complex....Pages 4-17
The Data and Statistical Analysis....Pages 18-27
Mechanisms of HLA and Disease Associations....Pages 28-31
Overview....Pages 32-48
Rheumatology and Joint Diseases....Pages 49-111
Dermatology....Pages 112-151
Neurology....Pages 152-184
Endocrinology....Pages 185-231
Gastroenterology....Pages 232-263
Ophthalmology....Pages 264-276
Malignancy....Pages 277-321
Allergy....Pages 322-334
Urogenital Diseases....Pages 335-351
Cardiovascular Diseases....Pages 352-362
Connective Tissue Diseases....Pages 363-378
Pulmonary Diseases....Pages 379-382
Infectious Diseases....Pages 383-401
Musculoskeletal Diseases....Pages 402-403
Psychiatric Diseases....Pages 404-414
Hematologic Diseases....Pages 415-424
Complement and Immune Deficiencies....Pages 425-430
Immune Response....Pages 431-444
Miscellaneous Diseases....Pages 445-463
Back Matter....Pages 465-472

✦ Subjects

Allergology; Immunology; Human Genetics