HLA-A2 allelic microvariants in nasopharyngeal carcinoma

✍ Scribed by E. C. Ren; Grace C. T. Law; S. H. Chan

• Book ID: 102276134
• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: French
• Weight: 347 KB
• Volume: 63
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910630211

✦ Synopsis

Abstract

HLA‐A2‐positive nasopharyngeal carcinoma (NPC; n = 38) and normal control (n = 51) populations were analysed by high‐resolution oligotyping to identify A2 allelic microvariants. Within the control group, A*0207 was found to be the most common allele, accounting for 50% of the A2 frequency in normals. In contrast, this allele was found to be present in only 23% of NPC cases, suggesting a protective effect. Of these 9 NPC patients with A*0207, all were associated with B46, unlike in the control group, where it can be found associated with non‐B46 antigens. Another allele, A*0201, which was thought to be protective against NPC was in fact present in 39.5% of NPC patients, more than twice the frequency in controls. These data confirm that A*0201 is not a protective allele for NPC, and other factors such as the A*0207, non‐B46 haplotype are of greater importance.