HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin

Cytotoxic CD4+ and CD8+ T lymphocytes, g

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12VAL) peptide vaccination of a patient, recognize 12VAL-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

✍ Marianne K. Gjertsen; Jens Bjørheim; Ingvil Saeterdal; June Myklebust; Gustav Ga 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB 👁 1 views

Mutant p21-ras proteins contain sequences that distinguish them from normal ras, and represent unique epitopes for T-cell recognition of antigen-bearing tumour cells. Here, we examined the capacity of CD4 ؉ and CD8 ؉ T cells, generated simultaneously by mutant-ras-peptide vaccination of a pancreatic