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HL-A Frequencies in Down's syndrome

✍ Scribed by David J. Segal; Joy W. Schlaut; Henry F. Pabst; Ernest E. McCoy; John B. Dossetor

Book ID
104703909
Publisher
Springer
Year
1975
Tongue
English
Weight
215 KB
Volume
27
Category
Article
ISSN
0340-6717

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✦ Synopsis

HL-A antigen frequencies were examined in 76 Down's syndrome individuals and 733 normal Caucasians. 10 antigens of the first locus and 15 antigens of the second locus were defined, using a microlymphocytotoxicity technique. No significant differences were observed between the normal and Down's syndrome samples, in contrast to a previous report (Boxer and Yokoyama, 1972) of decreased HL-A antigen frequencies in Down's syndrome individuals. Our results therefore suggest that there is no relationship between trisomy 21-associated immune aberrations and altered HL-A antigen frequencies.

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