HL-A and ABO antigens and malignant melanoma. A study of 212 cases

✍ Scribed by L. U. Lamm; F. Kissmeyer-Nielsen; K. E. Kjerbye; Bent Mogensen; N. C. Petersen

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 307 KB
• Volume: 33
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197405)33:5<1458::aid-cncr2820330532>3.0.co;2-t

✦ Synopsis

T w o hundred twelve melanoma patients, including 38 prospective and 174 retrospective cases, were ABO and HL-A typed, a n d the results were compared with those obtained in a sample of 562 healthy controls. T h e phenotype frequencies within the ABO system were identical i n patients and controls. A lower frequency of HL-A7 (significant a t the 5% level) was observed in the melanoma patients. Furthermore, deviations from the controls were observed in the following subgroups of patients: a deficiency of HL-A7 in the female patients (5% level); and a surplus of HL-A1 (1% level) and W19 (5% level) in patients with chances of 5-year corrected survival rates of 0-19% a n d 20-79%, respectively. However, although statistically significant, the deviations should a t From the University Hospital of Aarhus, Denmark.

* Blood Bank and Tissue Typing Laboratory.