Hiv integrase: a target for aids therapeutics
β Scribed by Mark Thomas; Leo Brady
- Book ID
- 114152854
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 619 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-7799
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract HIVβ1 integrase is a protein of Mr 32β000 encoded at the 3β²βend of the __pol__ gene. Integration of HIV DNA into the host cell chromosomal DNA apparently occurs by a carefully defined sequence of DNA tailoring (3β²βprocessing (3β²P)) and coupling (integration) reactions. Integration of HI
Current antiviral strategies against HIV rely on structureβfunction analysis of HIV reverse transcriptase (RT) and protease (PR). The third viral __pol__ gene product, HIV integrase (IN), is also a good target for drug discovery, since IN is essential for retroviral replication and, moreover, it has
## Abstract One of the three key enzymes encoded by the __pol__ gene of HIV is a __M__~r~ 32β000 protein called HIV integrase. This viral enzyme is involved in the integration of HIV DNA into host chromosomal DNA. There appears to be no functional equivalent of the enzyme in human cells. The bioche