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HIV infection: how effective is drug combination treatment?

✍ Scribed by Zvi Grossman; Mark Feinberg; Vladimir Kuznetsov; Dimiter Dimitrov; William Paul

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
171 KB
Volume
19
Category
Article
ISSN
0167-5699

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✦ Synopsis

The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.

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