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HIV excretion patterns and specific antibody responses in body fluids

✍ Scribed by Siobhan O'Shea; Mark Cordery; Winsome Y. Barrett; Douglas D. Richman; Caroline Bradbeer; Jangu E. Banatvala

Book ID: 102908110
Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 657 KB
Volume: 31
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890310409

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✦ Synopsis

Abstract

HIV excretion patterns and specific antibody responses were evaluated in blood, semen, female genital secretions, saliva, and crevicular fluid. Samples were examined for infectious virus, viral antigens, viral nucleic acid, HIV specific IgG, IgA, anti‐nef, and anti‐p24. Viral load in peripheral blood appeared to increase with disease progression. The proportion of patients with antibody responses specific for nef and p24 was also lower among patients with more advanced disease. Infectious virus and viral antigens were detected infrequently and at lower levels in body fluids than in blood, which may reflect the presence of local antibodies. HIV nucleic acid was detected in some semen and saliva samples in the absence of infectious virus.

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