HIV-1 reverse transcriptase inhibitory principles from Chamaesyce hyssopifolia

✍ Scribed by Yasmina A. Lim; Ma Chao Mei; Ines T. Kusumoto; Hirotsugu Miyashiro; Masao Hattori; Mahabir P. Gupta; Mireye Correa

• Book ID: 101287392
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 134 KB
• Volume: 11
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199702)11:1<22::aid-ptr951>3.0.co;2-3

✦ Synopsis

In the course of our studies on the development of anti-acquired immunodeficiency syndrome (AIDS) agents, we isolated corilagin, quercetin 3-O-␤-D-glucopyranoside and 1,3,4,6-tetra-O-galloyl-␤-D-glucopyranose from

Chamaesyce hyssopifolia, as the main inhibitory substances against human immunodeficiency virus (HIV) reverse transcriptase, an enzyme essential for the proliferation of HIV. The IC 50 of these substances were 20, 50 and 86 M, respectively, their modes of inhibition being non-competitive with respect to the substrate.