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HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: An investigation into the role of the P1' side chain on structure-activity

✍ Scribed by Young, Steven D.; Payne, Linda S.; Thompson, Wayne J.; Gaffin, Neil; Lyle, Terry A.; Britcher, Susan F.; Graham, Samuel L.; Schultz, Thomas H.; Deana, Albert A.


Book ID
126429733
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
981 KB
Volume
35
Category
Article
ISSN
0022-2623

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Peptidomimetic inhibitors of human immunodeficiency virus-1 protease are successful lead substances for the development of virostatic drugs against HIV as the causative agent of acquired immunodeficiency syndrome (AIDS). The hydroxyethylamine isostere of the proteolytic cleavage intermediate provide