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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes

✍ Scribed by Baltimore, David; Collins, Kathleen L.; Chen, Benjamin K.; Kalams, Spyros A.; Walker, Bruce D.

Book ID
109767050
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
348 KB
Volume
391
Category
Article
ISSN
0028-0836

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The HIV-1 Nef protein down-modulates surface expression of MHC class I proteins. Primary infected T lymphocytes thus escape lysis by cytotoxic T lymphocytes (CTL). In contrast, during HIV-1 infection there are strong CTL responses to several HIV proteins, and there is mounting evidence that CTL are