HIV-1: Molecular Biology and Pathogenesis

✍ Scribed by Kuah-Teh Jeang (Eds.)

• Publisher: Elsevier, Academic Press
• Year: 2000
• Tongue: English
• Leaves: 561
• Series: Advances in Pharmacology 49
• Edition: 1
• Category: Library

✦ Synopsis

The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Key Features Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications: An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs* The latest developments in HIV-vaccine research

✦ Table of Contents

Content:
Editorial Board
Page ii

Contributors
Pages xv-xvii

Preface
Pages xix-xxi
Kuan-Teh Jeang

HIV therapeutics: Past, present, and future Original Research Article
Pages 1-40
Osama Abu-ata, Jihad Slim, Geirge Perez, Stephen M. Smith

HIV drug resistance and viral fitness Original Research Article
Pages 41-66
François Clavel, Esther Race, Fabrizio Mammano

Inhibitors of HIV- I reverse transcriptase Original Research Article
Pages 67-109
Michael A. Parniak, Nicolas Sluis-Cremer

HIV-I protease: Maturation, enzyme specificity, and drug resistance Original Research Article
Pages 111-146
John M. Louis, Irene T. Webert, József Tözsér, G. Marius Clore, Angela M. Gronenborn

HIV-I integrase inhibitors: Past, present, and future Original Research Article
Pages 147-156,IN1,157-165
Nouri Neamati, Christophe Marchand, Yves Pommier

Selection of HIV replication inhibitors: Chemistry and biology Original Research Article
Pages 167-197
Seongwoo Hwang, Natarajan Tamilarasu, Tariq M. Rana

Therapies directed against the rev axis of HIV autoregulation Original Research Article
Pages 199-228
Andrew I. Dayton, Ming Jie Zhang

HIV-I gene therapy: Promise for the future Original Research Article
Pages 229-261
Ralph Dornburg, Roger J. Pomerantz

Assessment of HIV vaccine development: Past, present, and future Original Research Article
Pages 263-314
Michael W. Cho

HIV-I-associated central nervous system dysfunction Original Research Article
Pages 315-385
Fred C. Krebs, Heather Ross, John McAllister, Brian Wigdahl

Molecular mechanisms of human immunodeficiency virus type I mother-infant transmission Original Research Article
Pages 387-416
Nafees Ahmad

Molecular epidemiology of HIV-I: An example of Asia Original Research Article
Pages 417-436
Mao-Yuan Chen, Chun-Nan Lee

Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and Prevention Original Research Article
Pages 437-477
Vanessa M. Hirsch, Jeffrey D. Lifson

Animal models for AIDS pathogenesis Original Research Article
Pages 479-514
John J. Trimble, Janelle R. Salkowitz, Harry W. Kestler

Index
Pages 515-526

Contents of previous volumes
Pages 527-538