𝔖 Bobbio Scriptorium
✦   LIBER   ✦

HIV-1 integrase inhibitor

✍ Scribed by E. Eich


Book ID
113411115
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
122 KB
Volume
1
Category
Article
ISSN
1359-6446

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## Abstract The integration of viral cDNA into the host genome is an essential step in the HIV‐1‐life cycle and is mediated by the virally encoded enzyme, integrase (IN). Inhibition of this process provides an attractive strategy for antiviral drug design. The discovery of β‐diketo acid inhibitors

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## Abstract HIV‐1 integrase (IN) catalyzes the integration of proviral DNA into the host genome, an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive strategy for antiretroviral drug design. Currently two IN inhibitors, MK‐0518 and GS‐9137, are in adva

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In recent years, HIV-1 integrase (IN) has become an attractive target for designing antiretroviral agents. The first IN inhibitor approved for clinical use, raltegravir, has validated the pharmacological viability of IN inhibitors and signals the advent of a new generation of antiretroviral drugs. T

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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