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HIV-1-infected and/or immune-activated macrophages regulate astrocyte CXCL8 production through IL-1β and TNF-α: Involvement of mitogen-activated protein kinases and protein kinase R

✍ Scribed by Jialin C. Zheng; Yunlong Huang; Kang Tang; Min Cui; Doug Niemann; Alicia Lopez; Susan Morgello; Shengdi Chen


Book ID
113730340
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
966 KB
Volume
200
Category
Article
ISSN
0165-5728

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## Abstract Stromal cell‐derived factor 1 alpha (SDF‐1α) and its receptor CXCR4 play important roles in the pathogenesis of human immunodeficiency virus type one (HIV‐1)‐associated dementia (HAD) by serving as a HIV‐1 co‐receptor and affecting cell migration, virus‐mediated neurotoxicity, and neuro