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HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells

✍ Scribed by Karlhans F. Che; Rachel L. Sabado; Esaki M. Shankar; Veronica Tjomsland; Davorka Messmer; Nina Bhardwaj; Jeffrey D. Lifson; Marie Larsson


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
486 KB
Volume
40
Category
Article
ISSN
0014-2980

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## Abstract The basis of the adjuvant effect of IL‐1 on the clonal expansion of Ag‐specific CD4 T cells was measured __in vivo__ using the TCR transgenic T cell adoptive transfer method. Injection ofAg plus IL‐1 caused naive CD4 T cells to proliferate to a greater extent than did injection of Ag al