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From Hit to Lead: De Novo Design Based o

From Hit to Lead: De Novo Design Based on Virtual Screening Hits of Inhibitors of tRNA-Guanine Transglycosylase, a Putative Target of Shigellosis Therapy

✍ Ruth Brenk; Hans-Dieter Gerber; Jeffrey D. Kittendorf; George A. Garcia; Klaus R 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 299 KB 👁 1 views

## Abstract Shigellosis, a bacterial disease, causes the death of more than one million people per year. Extensive studies of __Shigella flexneri__ have recognized tRNA‐guanine transglycosylase (TGT, EC 2.4.2.29) as one of the key enzymes involved in the regulation of bacterial virulence. Based on