History of recurrent mucocutaneous herpes correlates with relatively low interferon production by herpes simplex virus-exposed cultured monocytes
✍ Scribed by Dr. Kimmo H. Linnavuori
- Book ID
- 102905721
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 527 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0146-6615
No coin nor oath required. For personal study only.
✦ Synopsis
Monocytes separated from blood specimens of healthy voluntary blood donors were infected with herpes simplex virus (HSV) 1 or 2. The amount of interferon produced by the HSV-exposed monocytes was found to be donor-specific and was similar whether tested with HSV I or HSV 2. The interferon levels in repeated blood specimens from a given donor were relatively stable within an observation period of a few months. The survey was expanded by testing 27 persons with history of recurrent herpes disease and I6 control persons without such history. HSV-exposed monocytes of the controls produced significantly higher amounts of interferon than those of the patients with lesions of recurrent herpes (mean levels 145 and 58 IU/ml, respectively; P < 0.05). A correlation was also found between the antibody status of the cell donor and the capability of the monocytes to produce interferon when infected with HSV 1 or HSV 2: the interferon responses of monocytes of seronegative cell donors were significantly higher than those of cultures from donors with complement fixing antibodies against HSV (P < 0.01).