History of Genetic Disease: The molecular genetics of Huntington disease — a history
✍ Scribed by Bates, Gillian P.
- Book ID
- 109952182
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 476 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1471-0056
- DOI
- 10.1038/nrg1686
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## Abstract Twelve Italian families with Huntington disease were tested with 10 probes known to be linked to the disease locus and able to detect polymorphisms at the following loci on chromosome 4: D4S10, D4S127, D4S95, D4S43, D4S115, D4S111, D4S90. The results confirmed the applicability of the l
In this paper we consider a model in which genetic factors that control aging also modify expression of the Huntington disease (HD) gene. Significant correlation coefficients were obtained for age-at-onset (AO) and age-at-death (AD) between affected parents and their affected offspring. However, mor