NURR1 Mutations in cases of schizophreni
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Buervenich, Silvia ;Carmine, Andrea ;Arvidsson, Mariette ;Xiang, Fengqing ;Zhang
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Article
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2000
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John Wiley and Sons
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English
⚖ 297 KB
Transgenic mice lacking the nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) fail to develop mesencephalic dopamine neurons. There is a highly homologous NURR1 gene in humans (formerly known as NOT) which therefore constitutes a good candidate gene for neurologic and psychiatric di